Huang Lab @ UCSD Bioengineering

Digital Molecular Biotechnology and Nanodevice Engineering

Our research focuses on developing digital molecular, micro and nano technologies to decode the molecular circuitry and operating systems (OS) of living systems. Applying the fundamental principles and state-of-the-art tools of molecular biology, chemistry, physics, mathematics, computer science, electrical engineering and materials science, we aim to develop technologies and engineer devices for single-molecule sequencing and digital counting of DNA/RNA and proteins in single cells, or any biological/clinical samples. These precise digital measurements will enable better computational modeling and deterministic understanding of living systems, and human physiology and diseases for basic research and biomedical applications. Our current research areas:

· Molecular and nano technologies for single-molecule DNA/RNA and protein sequencing

· Genomics, proteomics and medical diagnostics

· Lab-on-a-chip microfluidics, protein and nano device engineering

· DNA data storage and molecular computing

· Physical modeling, numerical simulations and deep machine learning